Milk fermented by a culture containing 107 CFU/ml of our particular probiotic, is considered to be a probiotic yoghurt drink. This means that the product supports a healthy digestion and boosts the  immune system. 

 

Definition of probiotics 

In 2001 the WHO/FAO for the first time officially defined the term ‘probiotics’. Probiotics are thereby  ‘live microorganisms that when administered in adequate amounts, confer a health benefit on the  host’.1 In practice this implies that in order to be probiotic, a bacterium should have the ability to survive  the gastro-intestinal tract, thus being resistant to bile and high acidity, and should subsequently be able  to proliferate in the gut. The abilities and the claimed health benefit have to be proven in at least one  human study, and any probiotic effect can only be claimed for a probiotic dose equal to that was used in  the study.2 

 

History of safe use 

Our probiotic strain is the world’s most documented probiotic strain. It has been used worldwide since 1990 as an ingredient in food and dietary supplements with no safety issues.  

It has been extensively studied across various health areas, in newborns,3 preterm infants,4children,5, 6, 7 pregnant women,8, 9 adults10 and in the elderly,11 with no safety issues. It is safe for human  consumption and in Europe has been granted QPS (Qualified Presumption of Safety) status12 and been  the subject of a GRAS (Generally Recognized As Safe) notice to the US Food and Drug Administration,13 with no safety issues. 

Our probiotic strain has been described in more than 1000 publications, and 250 publications of human studies. 

 

Proven health benefits 

Our probiotic strain is associated with digestive health benefits. The FAO/WHO recommends that “probiotic products shown to confer defined health benefits on the host should be permitted to describe these specific health benefits”.2 

 

In children, some of the most researched health areas with our probiotic strain are:  

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• Loose and watery stools 

Our probiotic strain has been associated with fewer instances1 and shorter episodes of loose and watery stools7, 14, 15 and normal bowel habits.5, 15 

• Health conditions related to hospitalization  

Our probiotic strain has been associated with fewer hospitalization-related digestive system issues6 and fewer  respiratory tract discomfort that can occur following hospitalization.6

• Immune challenges related to respiratory health  

Our probiotic strain has been associated with fewer respiratory challenges,6 , 16fewer instances of respiratory  challenges that last more than three days,6, 16 and significantly less days with signs of respiratory  discomfort. 

• Oral health  

Based on human studies and microbiological evaluation, our probiotic strain has been associated with more  healthy teeth,17 and with lower levels of specific bacteria that contributes to poor oral health.18 

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In adults, some of the most researched health areas with our probiotic strain are:  

• Travel-related loose stools  

Our probiotic strain has been associated with a reduction in the incidence of loose stools that travelers commonly experience when traveling in countries, regions and areas which present more  chance of being exposed to unfamiliar bacteria.10 

• Immune health  

Our probiotic strain probiotic supplementation has been associated with significantly higher levels of antibodies  (natural proteins integral to immune system function), which suggests support for immune  health.19

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References 

1 Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document: The  International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and  appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506. 

2 FAO, WHO. Probiotics in food: health and nutritional properties and guidelines for evaluation. Rome:  Food and Agriculture Organization of the United Nations : World Health Organization; 2006.

3 Arvola, T., Laiho, K., Torkkeli, S., Mykkänen, H., Salminen, S., Maunula, L., & Isolauri, E. (1999).  Prophylactic Lactobacillus GG Reduces Antibiotic-Associated Diarrhea in Children With Respiratory  Infections: A Randomized Study. Pediatrics, 104(5), e64-e64. 

4 Underwood, M. A., Salzman, N. H., Bennett, S. H., Barman, M., Mills, D., Marcobal, A., ... & Sherman, M.  P. (2009). A randomized placebo-controlled comparison of two prebiotic/probiotic combinations in 

preterm infants: impact on weight gain, intestinal microbiota, and fecal short chain fatty acids. Journal  of pediatric gastroenterology and nutrition, 48(2), 216. 

5 Vanderhoof, J. A., Whitney, D. B., Antonson, D. L., Hanner, T. L., Lupo, J. V., & Young, R. J. (1999).  Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. The Journal of pediatrics,  135(5), 564-568. 

6 Hojsak, I., Abdović, S., Szajewska, H., Milošević, M., Krznarić, Ž., & Kolaček, S. (2010). Lactobacillus GG  in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics, 125(5),  e1171-e1177. 

7 Isolauri, E., Rautanen, T., Juntunen, M., Sillanaukee, P., & Koivula, T. (1991). A human Lactobacillus  strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children. Pediatrics,  88(1), 90-97. 

8 Gueimonde, M., Sakata, S., Kalliomäki, M., Isolauri, E., Benno, Y., & Salminen, S. (2006). Effect of  maternal consumption of lactobacillus GG on transfer and establishment of fecal bifidobacterial  microbiota in neonates. Journal of pediatric gastroenterology and nutrition, 42(2), 166-170.

9 Lahtinen, S. J., Boyle, R. J., Kivivuori, S., Oppedisano, F., Smith, K. R., Robins-Browne, R., ... & Tang, M. L.  (2009). Prenatal probiotic administration can influence Bifidobacterium microbiota development in  infants at high risk of allergy. Journal of Allergy and Clinical Immunology, 123(2), 499-501.

10 Oksanen, P. J., Salminen, S., Saxelin, M., Hämäläinen, P., Ihantola-Vormisto, A., Muurasniemi-Isoviita,  L., ... & Vapaatalo, H. (1990). Prevention of travellers diarrhoea by Lactobacillus GG. Annals of medicine,  22(1), 53-56. 

11 Hatakka, K., Ahola, A. J., Yli-Knuuttila, H., Richardson, M., Poussa, T., Meurman, J. H., & Korpela, R.  (2007). Probiotics reduce the prevalence of oral Candida in the elderly—a randomized controlled trial.  Journal of dental research, 86(2), 125-130. 

12 EFSA Panel on Biological Hazards (BIOHAZ). EFSA Journal. 2015;13:4331. 

13 Food and Drug Administration. GRAS Notice No GRN 000049. 2002. 

14 Sindhu, K. N., Sowmyanarayanan, T. V., Paul, A., Babji, S., Ajjampur, S. S., Priyadarshini, S., ... & Kang, G.  (2014). Immune response and intestinal permeability in children with acute gastroenteritis treated with  Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial. Clinical infectious  diseases, 58(8), 1107-1115. 

15 Aggarwal, S., Upadhyay, A., Shah, D., Teotia, N., Agarwal, A., & Jaiswal, V. (2014). Lactobacillus GG for  treatment of acute childhood diarrhoea: An open labelled, randomized controlled trial. The Indian journal  of medical research, 139(3), 379. 

16 Hojsak, I., Snovak, N., Abdović, S., Szajewska, H., Mišak, Z., & Kolaček, S. (2010). Lactobacillus GG in the  prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a  randomized, double-blind, placebo-controlled trial. Clinical Nutrition, 29(3), 312-316.

17 Näse, L., Hatakka, K., Savilahti, E., Saxelin, M., Pönkä, A., Poussa, T., ... & Meurman, J. H. (2001). Effect  of long–term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental  caries and caries risk in children. Caries research, 35(6), 412-420. 

18 Glavina, D., Goršeta, K., Škrinjarić, I., Negovetić Vranić, D., Mehulić, K., & Kožul, K. (2012). Effect of LGG  yoghurt on Streptococcus mutans and Lactobacillus spp. salivary counts in children. Collegium  antropologicum, 36(1), 129-132. 

19 Davidson, L. E., Fiorino, A. M., Snydman, D. R., & Hibberd, P. L. (2011). Lactobacillus GG as an immune  adjuvant for live-attenuated influenza vaccine in healthy adults: a randomized double-blind placebo controlled trial. European journal of clinical nutrition, 65(4), 501-507.